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  • Title: Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization.
    Author: Qumsiyeh MB, Valentine MB, Suttle DP.
    Journal: Genomics; 1989 Jul; 5(1):160-2. PubMed ID: 2767686.
    Abstract:
    The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization.
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