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  • Title: Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog.
    Author: Hahn KA, Richardson RC.
    Journal: J Am Vet Med Assoc; 1989 Aug 01; 195(3):351-3. PubMed ID: 2768061.
    Abstract:
    Cisplatin (cis-diammine-dichloroplatinum) treatment induced partial remission of pulmonary metastatic malignant mesenchymoma and nearly complete radiographic remission of hypertrophic osteopathy in a 14-year-old Beagle. Cisplatin was given once every 3 weeks. Clinical signs of hypertrophic osteopathy resolved one week after initiation of treatment. Partial remission of pulmonary metastases and partial radiographic remission of hypertrophic osteopathy was seen 6 weeks after initiation of treatment. Previous treatment of neoplasia-related hypertrophic osteopathy has consisted of removal of the initiating mass or vagotomy. In this case, appropriate chemotherapy was used to control clinical signs and progression of hypertrophic osteopathy.
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