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  • Title: Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper.
    Author: Ryu SM, Kwon J, Seo YH, Song EG, Hong SS, Kim BS, Hong JS, Ryu KH, Lee D.
    Journal: Virus Res; 2017 Jan 02; 227():49-56. PubMed ID: 27686478.
    Abstract:
    A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica. All isolated compounds exhibited inactivation effects in systemic host plants, and compounds 3 and 4 were potent, with a minimum inhibitory concentration of 10μM. Furthermore, compound 3 was found to have a protective effect at the tested concentration of 40μM.
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