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  • Title: Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes.
    Author: Elangovan S, Neumann J, Sortais JB, Junge K, Darcel C, Beller M.
    Journal: Nat Commun; 2016 Oct 06; 7():12641. PubMed ID: 27708259.
    Abstract:
    Borrowing hydrogen (or hydrogen autotransfer) reactions represent straightforward and sustainable C-N bond-forming processes. In general, precious metal-based catalysts are employed for this effective transformation. In recent years, the use of earth abundant and cheap non-noble metal catalysts for this process attracted considerable attention in the scientific community. Here we show that the selective N-alkylation of amines with alcohols can be catalysed by defined PNP manganese pincer complexes. A variety of substituted anilines are monoalkylated with different (hetero)aromatic and aliphatic alcohols even in the presence of other sensitive reducible functional groups. As a special highlight, we report the chemoselective monomethylation of primary amines using methanol under mild conditions.
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