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  • Title: [Effect of serotonin on the background activity of neurons in the isolated spinal cord semisegment of the rat].
    Author: Khasabov SG, Tamarova ZA.
    Journal: Neirofiziologiia; 1989; 21(3):335-43. PubMed ID: 2770915.
    Abstract:
    The background activity of neurons in the isolated lumbar semisegment of 14-22 days old white rats was investigated before and after bath application of serotonin (5-HT, 1.10(-8)-1.10(-4) mol/l). 50% investigated neurons in dorsal horn and 70.6% interneurons in the ventral horn reacted on 5-HT. Excitation reactions prevailed. In the dorsal horn 5-HT evoked activation in 62.4% of responding interneurons, depression--in 8.4% and mixed reaction--in 29.2%. In the ventral horn 91.6% of all responses were activation reactions and only 8.4%--biphase ones. 5-HT induced discharges of motoneurons in the ventral root and ventral root depolarization. The data obtained have shown mainly the activation effect of 5-HT on the background activity of spinal neurons.
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