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  • Title: Combined Effect of Low-Intensity Helium-Neon Laser and X-Ray Radiation on in Vivo Cellular Response of the Whole Blood and Lymphoid Organs in Mice.
    Author: Zaichkina SI, Dyukina AR, Rozanova OM, Romanchenko SP, Sirota NP, Kuznetsova EA, Simonova NB, Sorokina SS, Zakrzhevskaya DT, Yusupov VI, Bagratishvili VN.
    Journal: Bull Exp Biol Med; 2016 Sep; 161(5):679-682. PubMed ID: 27709381.
    Abstract:
    We studied the effect of exposure to helium-neon laser (dose range 0.16-50 mJ/cm2) on activation of natural protection reserve in mice using the adaptive response test. DNA comets method revealed a protective response manifested in DNA damage level in whole blood leukocytes of mice and in lymphoid organs by the thymus and spleen weight index; preexposure to laser did not induce the adaptive response. ROS level in the whole blood was assessed by the level of zymosan-induced luminol chemiluminescence. In mice subjected to adaptive laser irradiation in doses of 0.16-5 mJ/cm2 followed by X-ray irradiation in a dose of 1.5 Gy, the activation index calculated as the ratio of induced to spontaneous area of luminescence was by 1.4 times lower than that in non-irradiated animals, which attested to reduced ROSgeneration reserve capacity of neutrophils.
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