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  • Title: Effect of Hedgehog Signaling Pathway Activation on Proliferation of High-Grade Gliomas.
    Author: Cherepanov SA, Cherepanova KI, Grinenko NF, Antonova OM, Chekhonin VP.
    Journal: Bull Exp Biol Med; 2016 Sep; 161(5):674-678. PubMed ID: 27709388.
    Abstract:
    We studied the effect of an activator (ShTh) and an inhibitor (cyclopamine) of the Hedgehog signaling pathway on proliferation of human glioma cell lines U87-MG and U251-MG and cultured human astrocytes. The Hedgehog signaling pathway is activated in glioma cells, but not in cultured human astrocytes. Experiments with Shh and cyclopamine can serve as an additional criterion for assessing activity of Hedgehog signaling in known cell lines and primary cultured cells.
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