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  • Title: Recovery of hippocampal cholinergic activity by transplantation of septal neurons in AF64A treated rats.
    Author: Ikegami S, Nihonmatsu I, Hatanaka H, Takei N, Kawamura H.
    Journal: Neurosci Lett; 1989 Jun 05; 101(1):17-22. PubMed ID: 2771150.
    Abstract:
    Embryonic septal neurons were transplanted into the hippocampus of adult rats which had received lateral-ventricular administration of AF64A, a cholinergic neurotoxin, and the effects on hippocampal cholinergic activity were studied. One week after AF64A administration, we injected dissociated septal cell suspension into the dorsal hippocampus, unilaterally. About 3 months after the transplantation, acetylcholine (ACh)-rich septal grafts formed extensive acetylcholinesterase (AChE)-positive fibers into the host hippocampus, recovering choline acetyltransferase (ChAT) level only in the grafted side. These results indicate that septal implants can produce a partial recovery of the cholinergic activity in the chemically damaged hippocampus.
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