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  • Title: Electrophysiological analysis of the neural circuitry underlying opiate effects in the nucleus accumbens septi.
    Author: Hakan RL, Callaway C, Henriksen SJ.
    Journal: Neurosci Lett; 1989 Jun 19; 101(2):163-8. PubMed ID: 2771162.
    Abstract:
    Systemically administered opiates inhibit or excite spontaneously active single units of the nucleus accumbens septi (NAS) but do not affect fimbria-evoked NAS responses. However, microinjections of morphine to the dopamine cell bodies of the ventral tegmental area (VTA-M) do inhibit these evoked responses. Since systemic heroin can reverse the inhibitory effect of VTA-M on the fimbria-evoked NAS responses, systemic opiates might exert actions on other brain regions that oppose the inhibitory effect of VTA-M on the NAS. Evidence is provided indicating that this opposing action can arise from opiate actions at the ventral subiculum of the hippocampus.
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