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  • Title: [Increased androgen-binding capacity and decreased free androgen index in male alcoholics with liver disease].
    Author: Szarvas F, Regényi J, Tóth I, Faredin I.
    Journal: Orv Hetil; 1989 Jul 23; 130(30):1597-601. PubMed ID: 2771393.
    Abstract:
    Androgen binding capacity in the serum of 30 male patients under 51 years of age suffering from chronic alcoholic liver disease was investigated with tritiated 5 alpha-dihydrotestosterone. The result received by saturation analysis is regarded as an indicator of the SHBG (sex hormone binding globulin) content of the blood. Testosterone was measured simultaneously and the free androgen index (FAI) was calculated. The diagnosis of liver disease was based on case histories, physical symptoms and laboratory abnormalities, in some cases on liver biopsy too. Age-matched control group consisted of 18 healthy males. The results showed markedly elevated androgen binding capacities (SHBG contents), testosterone values in the normal range and significantly decreased FAI, indicating insufficient amounts of biologically active testosterone.
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