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  • Title: Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
    Author: Maiti M, Gao LJ, Huang C, Ptak RG, Murray MG, De Jonghe S, Herdewijn P.
    Journal: Org Biomol Chem; 2016 Sep 21; 14(37):8743-8757. PubMed ID: 27714209.
    Abstract:
    In an attempt to identify novel nucleoside phosphoramidate analogues for improving the anti-HCV activity of 2'-C-Me-uridine, we have synthesized for the first time a series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine. Evaluation of their activity against HCV revealed that they displayed very potent anti-HCV activity, with EC50 values that are in the same range as of Sofosbuvir.
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