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  • Title: Transmission of residues to eggs following long-term administration of 14C-labelled deoxynivalenol to laying hens.
    Author: Prelusky DB, Hamilton RM, Trenholm HL.
    Journal: Poult Sci; 1989 Jun; 68(6):744-8. PubMed ID: 2771843.
    Abstract:
    The transmission of radioactive residues of 14C-labelled deoxynivalenol (DON; vomitoxin) to eggs was investigated during prolonged administration of low levels of DON-contaminated feed to White Leghorn chickens. Laying hens were provided with a 5.5 ppm 14C-DON-spiked diet (.55 mg DON; .8.25 microCi bird/day) for a 65-day period, after which they received a clean, unadulterated diet for 21 days. Total residues (based on specific radioactivity) increased daily until the 8th day of 14C-DON exposure, when levels reached a plateau for several days, then decreased slowly thereafter. Maximum radioactivity measured was equivalent to 1.7 micrograms DON or metabolites per 60-g egg; the yolk, albumen, and shell membrane contributed 70, 29, and 1% of the total amount, respectively. By Day 30, levels had declined to 25% of peak levels (.40-micrograms DON equivalents/egg) and remained relatively constant until the spiked feed was removed at Day 65, at which time residues quickly declined to negligible values. These findings indicate that although very low concentrations of DON can be found in eggs under these feeding conditions, levels are so low that a potential health hazard to humans would likely be minimal.
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