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  • Title: Linking gene regulation to cell behaviors in the posterior growth zone of sequentially segmenting arthropods.
    Author: Williams TA, Nagy LM.
    Journal: Arthropod Struct Dev; 2017 May; 46(3):380-394. PubMed ID: 27720841.
    Abstract:
    Virtually all arthropods all arthropods add their body segments sequentially, one by one in an anterior to posterior progression. That process requires not only segment specification but typically growth and elongation. Here we review the functions of some of the key genes that regulate segmentation: Wnt, caudal, Notch pathway, and pair-rule genes, and discuss what can be inferred about their evolution. We focus on how these regulatory factors are integrated with growth and elongation and discuss the importance and challenges of baseline measures of growth and elongation. We emphasize a perspective that integrates the genetic regulation of segment patterning with the cellular mechanisms of growth and elongation.
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