These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Oxygen cathode measurements and radiation response in tumour-bearing mice treated with misonidazole.
    Author: Davies RW, Hall WS.
    Journal: Br J Cancer Suppl; 1978 Jun; 3():154-8. PubMed ID: 277216.
    Abstract:
    Direct measurements using 200 micron oxygen cathode electordes have been made in tumour and subcutaneous tissues of anaesthetized C3H mice treated with misonidazole. In air-breathing animals a six-fold increase in tumour oxygen cathode readings was observed by 23 min after i.p. injection of misonidazole at 0.5 mg/g body weight. A similar rise, but of 2.5 times, was observed for the subcutaneous tissues. Comparison of tumour oxygen readings for drug-treated and control mice breathing 100% O2 at different pressures showed markedly increased levels for the drug-treated animals. Tumour response to radiation was measured for 250 kV X-rays and 15 MeV electrons. In each case, when a dose of radiation was combined with pre-treatement with misonidazole an increased radiation response was observed when compared with the same dose of radiation given alone. At the highest dose (40 Gy) there was a suggestion of an increased normal tissue reaction. The significance of the measurements is discussed.
    [Abstract] [Full Text] [Related] [New Search]