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  • Title: Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.
    Author: Sutherland R, Macfarlane W.
    Journal: Br J Cancer Suppl; 1978 Jun; 3():168-72. PubMed ID: 277220.
    Abstract:
    Spheroids of EMT6 tumour cells were grown in spinner culture. As with V79 cell spheroids, the combination of 1.5mM misonidazole and hyperthermia at 42.5 degree C for 1 or 2 h cuased greater cytotoxicity than either heat or drug alone. Radioresistant hypoxic cells at the centre of the spheroids were eliminated but other cells were also killed.
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