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  • Title: The demonstration of in vivo misonidazole tumour toxicity using post radiation hypoxia.
    Author: Gomer CJ, Johnson RJ, Hetzel FW, Lawrence G.
    Journal: Br J Cancer Suppl; 1978 Jun; 3():228-31. PubMed ID: 277234.
    Abstract:
    The cytotoxic effect of the radiosensitizer misonidazole on hypoxic tumour cells in vivo has been studied. Using standard procedures of large single doses of X-ray (30 Gy) followed by 1.0 mg/g misonidazole, no significant cytotoxicity (measured by tumour regrowth) could be observed. In contrast, when utilizing post radiation hypoxia (3 h of 7% oxygen breathing) in conjunction with post radiation misonidazole, an increased amount of direct drug toxicity was demonstrated. The use of this acute hypoxia treatment may prove to be a useful tool for measuring various in vivo radiobiological responses.
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