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  • Title: The effect of the radiosensitizer misonidazole on motor nerve conduction velocity in the mouse.
    Author: Hirst DG, Vojnovic B, Stratford IJ, Travis EL.
    Journal: Br J Cancer Suppl; 1978 Jun; 3():237-41. PubMed ID: 277237.
    Abstract:
    The clinical use of misonidazole as a hypoxic cell radiosensitizer is at present limited by its neurotoxicity at high doses (Urtasun et al., 1977; Dische et al., 1977). An in vivo neurological end point, viz. measurement of nerve conduction velocity, has been developed to examine sensitizer action. Conduction velocity in mice was measured as a function of time after a single dose of misonidazole and as a function of drug dose. Doses greater than 0.33 mg/g produced significant transient reductions in velocity. The time course of the reduction in velocity closely followed the uptake/excretion profile of misonidazole from blood serum.
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