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  • Title: Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions.
    Author: Friciu M, Zaraa S, Roullin VG, Leclair G.
    Journal: PLoS One; 2016; 11(10):e0164577. PubMed ID: 27727306.
    Abstract:
    The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.
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