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  • Title: [The harmful action of ethanol on the liver: the role of alcohol dehydrogenase and aldehyde dehydrogenase].
    Author: Usatenko MS, Petrova MA, Sokolovskaia NE, Anakina RP, Borodkin IuS.
    Journal: Tsitologiia; 1989 May; 31(5):604-7. PubMed ID: 2773067.
    Abstract:
    White rats were divided into water-preferring (WP) and ethanol-preferring (EP) groups, on the basis of their preferable drink: either water or 15% solution of ethanol. Each of these groups was then subdivided into groups which were given to drink for 1 year 15% solution of ethanol (ethanol-treated) or water (controls). Alcohol dehydrogenase/aldehyde dehydrogenase activity ratios (ADH/AlDH) in livers of WP controls were considerably higher than those in EP controls. The difference in ADH/AlDH has somewhat decreased after ethanol treatment. However, this ratio remained the highest in the WP alcohol-treated group. The signs of proteinic and lipid dystrophy of the liver in alcohol-treated WP rats were expressed much more clearly than in all other groups. It is concluded that in the liver of animals with a high ADH/AlDH ratio there are favourable conditions for accumulation of a toxic hepatocyte-damaging acetaldehyde.
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