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  • Title: [Assessment of the degree of carcinogenicity of small doses of nitrites].
    Author: Il'nitskiĭ AP, Iurchenko VA, Zhukova GF, Ermilov VB.
    Journal: Vopr Onkol; 1989; 35(7):843-8. PubMed ID: 2773401.
    Abstract:
    Chronic experiments on CBA and C57B1 mice and acute experiments on CBA mice established: (a) carcinogenic effect of sodium nitrite given continuously with drinking water (0.1; 1.0 and 10.0 maximum allowable concentration) in combination with morpholine fed with bread, and (b) endogenous synthesis of nitrosomorpholine as a result of simultaneous intragastric administration of same doses of sodium nitrite and morpholine. Also, nitrosomorpholine and N-nitrosodimethylamine synthesis was observed in vitro following addition of low-dose sodium nitrite, morpholine and amidopyrine to human gastric juice. Carcinogenic hazard associated with low-dose nitrite consumption in humans is discussed.
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