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  • Title: [Effect of age and the duration of the peptic ulcer on reflux changes of the esophageal mucosa].
    Author: Simitchev S.
    Journal: Vutr Boles; 1989; 28(3):33-7. PubMed ID: 2773457.
    Abstract:
    446 patients with an active peptic ulcer were examined. In 81.2% of them gastroesophageal reflux was found. In 220 patients the changes in the esophageal mucosa were studied morphologically. The patients were classified into groups according to their age and the duration of the disease. In 70.3% of the patients with a history of peptic ulcer over 15 years a reflux esophagitis was found and in 34.5% of the patients it was well expressed while in only 39% of the patients with a 5 year history of the disease a reflux esophagitis was found histologically and it was well expressed in 8.1% of them. Gastroesophageal reflux and reflux esophagitis are more frequent in patients over 40 years of age and in these patients the more severe forms prevail. The longer is the duration of the disease the greater is the number of cases with well expressed destructive changes.
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