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  • Title: One-Step Homologation for the Catalytic Asymmetric Synthesis of Deoxypropionates.
    Author: Xu S, Li H, Komiyama M, Oda A, Negishi EI.
    Journal: Chemistry; 2017 Jan 01; 23(1):149-156. PubMed ID: 27739117.
    Abstract:
    A one-step homologation protocol for the synthesis of natural products containing deoxypropionate motif is described by the combination of Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)-Pd-catalyzed vinylation and ZACA-oxidation reaction. In contrast to most other synthetic strategies used to date that typically require three steps per deoxypropionate unit due to the functional-group interconversions, our one-step homologation strategy promises to provide a general and more efficient synthetic route toward deoxypropionate natural products as exemplified by significant improvements in the syntheses of intermediates and/or final products of mycolipenic acid 1 and its analogue 2, (-)-rasfonin, and syn- and anti-dicarboxylic acids 5 and 6.
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