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  • Title: Malignant epithelioid schwannoma of the skin. A low-grade neurotropic malignant melanoma?
    Author: Suster S, Amazon K, Rosen LB, Ollague JM.
    Journal: Am J Dermatopathol; 1989 Aug; 11(4):338-44. PubMed ID: 2774103.
    Abstract:
    We studied a polypoid cutaneous neoplasm excised from the left arm of a 23-year-old man by light microscopy, immunohistochemistry, and electron microscopy. Histologically, the tumor was composed of a proliferation of round to oval epithelioid cells that were arranged in fascicles and showed a prominent perineural distribution. Immunohistochemistry revealed the presence of S-100 protein and vimentin within tumor cells. Electron microscopy demonstrated reduplication of basal lamina and abundant long-spacing collagen in intercellular spaces. The findings are consistent with a primary malignant epithelioid schwannoma of the skin. We discuss the relationship of this lesion with other neoplasms in the spectrum of tumors showing schwannian and melanocytic lines of differentiation.
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