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  • Title: Endometriosis and pregnancy complications: a Danish cohort study.
    Author: Glavind MT, Forman A, Arendt LH, Nielsen K, Henriksen TB.
    Journal: Fertil Steril; 2017 Jan; 107(1):160-166. PubMed ID: 27743699.
    Abstract:
    OBJECTIVE: To study the association between endometriosis and risk of pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and small for gestational age (SGA), in a large Danish birth cohort, while taking fertility treatment into account. DESIGN: Population-based study. SETTING: Not applicable. PATIENT(S): A total population of 82,793 singleton pregnancies from the Aarhus Birth Cohort (1989 through 2013); 1,213 women had a diagnosis of endometriosis, affecting 1,719 pregnancies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and SGA. RESULT(S): Endometriosis was associated with an increased risk of preterm birth (adjusted odds ratio [AOR] 1.67, 95% confidence interval [CI] 1.37-2.05), with the risk being highest for very preterm birth (AOR 1.91, 95% CI 1.16-3.15). Compared with unaffected women, women with endometriosis also had an increased risk of pre-eclampsia (AOR 1.37, 95% CI 1.06-1.77) and cesarean section (AOR 1.83, 95% CI 1.60-2.09). Assisted reproductive technology did not explain these findings. No association was found between endometriosis and postpartum hemorrhage or SGA. CONCLUSION(S): Women with endometriosis were at increased risk of pre-eclampsia, preterm birth, and cesarean section, irrespective of use of assisted reproductive technology.
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