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  • Title: New milbemycin metabolites from the genetically engineered strain Streptomyces bingchenggensis BCJ60.
    Author: Li JS, Du MN, Zhang H, Zhang J, Zhang SY, Wang HY, Chen AL, Wang JD, Xiang WS.
    Journal: Nat Prod Res; 2017 Apr; 31(7):780-784. PubMed ID: 27748635.
    Abstract:
    Two new milbemycin derivatives, 27-methoxylmilbemycin α31 (1) and 27-oxomilbemycin α31 (2), were isolated from the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by 1D NMR, 2D NMR and HR-ESI-MS spectral analysis, and comparison with previous reports. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.
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