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  • Title: [Relationship between serum erythropoietin levels and brain injury in preterm infants].
    Author: Chen GF, Li HT, Huang JJ, Wang ZX, Li Y, Yang CZ, Wu BQ, Liu WL, Liu LH, Kong Q, Liu RT.
    Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2016 Oct; 18(10):947-952. PubMed ID: 27751209.
    Abstract:
    OBJECTIVE: To study the relationship between the levels of erythropoietin (EPO) in serum and brain injury in preterm infants. METHODS: Three hundred and four preterm infants (gestational age: 28-34 weeks) born between October 2014 and September 2015 were enrolled in this study. Brain injury was diagnosed using cerebral ultrasound and MRI. The levels of EPO, S100 protein, neuron-specific enolase (NSE) and myelin basic protein (MBP) in serum were detected using ELISA. To compare the incidence of brain injury in different serum EPO levels in preterm infants, and the relationship between brain injury and serum EPO levels was analyzed. RESULTS: The incidence rate of brain injury in preterm infants was 41.1% (125/304). The incidence rate of brain injury in the low EPO level group was significantly higher than that in the middle-high EPO level groups (P<0.01). The serum levels of S100 protein, NSE, and MBP in the brain injury groups were significantly higher than in the control group (P<0.01). The serum EPO levels were negatively correlated with serum S100 protein concentration and NSE levels (P<0.05). According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants. CONCLUSIONS: There is a higher incidence rate of brain injury in preterm infants with lower serum EPO levels. The serum EPO levels may be correlated with brain injury in preterm infants. 目的: 探讨早产儿血清促红细胞生成素（EPO）水平与脑损伤的关系。 方法: 选取2014年10月至2015年9月出生胎龄在28~34周的早产儿304例作为研究对象。采用颅脑B超和MRI检查诊断脑损伤，ELISA检测血清EPO、S100蛋白、神经元特异性烯醇化酶（NSE）和髓鞘碱性蛋白（MBP）水平，比较不同血清EPO水平早产儿脑损伤的发生率，分析血清EPO水平与各指标的相关性；采用多因素Logistic回归分析研究血清EPO水平与脑损伤的关系。 结果: 304例早产儿中发生脑损伤125例（41.1%）；低水平EPO组缺血性脑损伤发生率明显高于中高水平EPO组（P＜0.01）；脑损伤早产儿血清S100蛋白、NSE、MBP水平均高于无脑损伤组（P＜0.01）；血清EPO水平与S100蛋白浓度、NSE水平均呈负相关（P＜0.05，P＜0.01）；Logistic回归分析显示低胎龄、低出生体重、窒息复苏、机械通气时间延长、贫血和低血清EPO水平均是脑损伤发病的独立危险因素。 结论: 血清EPO低水平的早产儿脑损伤发生率高，血清EPO水平与早产儿脑损伤密切相关。
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