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  • Title: Heteroarylalkanoic acid with possible antiinflammatory activities. Note VII.
    Author: Gamberini G, Costantino L, Parenti C, De Salvia M, Di Bella M, Raffa L, Rossi T.
    Journal: Boll Chim Farm; 1989 Mar; 128(3):101-5. PubMed ID: 2775522.
    Abstract:
    A series of 3-(4H-1,2,4-benzothiadiazine-1,1-dioxide-3-ylamino)-propanoic acids was synthesized in order to study their possible antiinflammatory activity and to compare it with the corresponding homologous or isoster series previously studied. Of particular interest is parent compound 1, which is unsubstituted in the benzenoid moiety and exerts a very marked inhibitory effect on carrageenan-induced plantar oedema greater than that observed for any of the terms of the other series hitherto studied. The possible influence of some chemico-physical parameters on the occurrence of this antiinflammatory activity is investigated.
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