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  • Title: Synthesis and hypolipidemic activity of some new esters of glycerol and 2-O-methyl-glycerol with nicotinic and 5-fluoro-nicotinic acids.
    Author: Dall'Asta L, Comini A, Borella F, Berti MA, Coppi G.
    Journal: Boll Chim Farm; 1989 Mar; 128(3):106-10. PubMed ID: 2775523.
    Abstract:
    A series of new esters of glycerol and 2-O-methyl-glycerol with nicotinic and 5-fluoro-nicotinic acids were synthesized and their hypolipidemic activities were comparatively tested. The two most interesting compounds, 5 and 12, show a higher activity than both nicotinic and 5-fluoro-nicotinic acids in the following experimental models: Triton and olive oil hyperdyslipemia and tests on old rats.
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