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  • Title: [Acid-base balance, blood lactate, blood pyruvate, and L/P ratio in albino rats raised in normobaric, hypoxic hypoxia for one or two generations].
    Author: Quatrini U, Licciardi A, Morici G.
    Journal: Boll Soc Ital Biol Sper; 1989 Apr; 65(4):357-64. PubMed ID: 2775542.
    Abstract:
    Albino rats Wistar family raised in normobaric hypoxic environment (10% O2 in N2) since one or two generations showed a displacement of the acid-base balance of the arterial blood towards acidosis and an increase of blood lactate and pyruvate when compared with normoxic controls. Found differences were significant in all considered parameters except for lactate-pyruvate ratio. Moreover in hypoxic animals of second generation these differences were quantitatively less strong. In effect when we compared the two groups of hypoxic animals between them, they showed significant differences-estimated with Duncan's test - in the pH, B.E., S.B., lactate and pyruvate values. All the above mentioned differences pointed out less blood acidification and less increase of lactate and pyruvate in hypoxic animals of second generation. The results seem to indicate the beginning of adaptative processes to the extraordinary hypoxic normobaric environment in albino rat and the evolution of these processes when named species remain in hypoxic environment for more than one generation.
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