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  • Title: [Glanzmann's thrombasthenia and pregnancy. Contribution of plasma exchange before scheduled cesarean section].
    Author: Vivier M, Treisser A, Naett M, Diemunsch P, Schmitt JP, Waller C, Tongio MM, Hemmendinger S, Lutz P.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 1989; 18(4):507-13. PubMed ID: 2778287.
    Abstract:
    Glanzmann's thrombasthenia is a thrombopathy which affects primary hemostasis due to a qualitative or quantitative abnormality of membrane glycoproteins IIb-IIIa. The treatment of hemorrhages is usually associated with the transfusion of packed red blood cells and platelet concentrates. If massive allo-immunisation occurs, the transfusion will prove to be inefficient. A case of a cesarean section was scheduled after therapeutic plasmapheresis and platelet transfusions in a massively allo-immunised patient with Glanzmann's thrombasthenia. The plasma exchange made it possible to reduce to trace levels the concentrations of anti-PLA1 and anti-PLA2 antibodies, thus making platelet transfusions hemostatically efficient. The cesarean section was therefore safely performed when the bleeding time was normalized.
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