These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Expression of microRNA-152 in colorectal cancer and its relationship with prognosis].
    Author: Wang Y, Yuan W, Ma X, Ma J.
    Journal: Zhonghua Zhong Liu Za Zhi; 2016 Oct 23; 38(10):763-766. PubMed ID: 27784461.
    Abstract:
    Objective: The aim of this study was to detect the expression level of miR-152 in colorectal cancer (CRC) and adjacent tissues, and to explore its relationship with clinicopathological features and potential to be a prognosis biomarker in CRC patients. Methods: The expression of miR-152 was detected by real-time quantitative PCR in 202 colorectal cancer and adjacent colorectal tissues. Cox proportional hazard model was used to analyze the relationship between the expression level of miR-152 and prognosis of colorectal cancer patients. Results: The expression of miR-152 in colorectal cancer and adjacent colorectal tissues was 2.109±0.217 and 15.860±6.647, respectively, with a significant difference between the two groups (P<0.001). Comparing colorectal cancer with lymph node metastasis to those without lymph node metastasis, the expression of miR-152 (2.582±0.344 vs. 1.640±0.258) was significantly increased (P=0.001). In addition, the expression of miR-152 in CRC according to TNM staging was 1.640±0.258 in stage Ⅰ/Ⅱ, 2.187±0.361 in stage Ⅲ and 4.403±0.877 in stage Ⅳ, showing a gradual increase depending on clinical staging (P<0.05). Univariate Cox regression analysis indicated that lymph node metastasis, degree of differentiation, TNM stage and miR-152 expression level were related to the postoperative survival of colorectal cancer patients (P<0.05). Multivariate Cox regression analysis showed that degree of differentiation and TNM stage were independent factors affecting the survival of colorectal cancer patients (P<0.001). The results of survival analysis indicated that high expression level of miR-152 was related to a poor prognosis of CRC cancer. Conclusions: The expression level of miR-152 is reduced in colorectal cancer comparing with adjacent colorectal tissues. High expression level of miR-152 is associated with lymph node metastasis and TNM stage of CRC. MiR-152 is a potential marker for prognosis in colorectal cancer.
    [Abstract] [Full Text] [Related] [New Search]