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  • Title: HLA-A29 and genetic susceptibility to chromoblastomycosis.
    Author: Tsuneto LT, Arce-Gomez B, Petzl-Erler ML, Queiroz-Telles F.
    Journal: J Med Vet Mycol; 1989; 27(3):181-5. PubMed ID: 2778577.
    Abstract:
    The distribution of 12 HLA-A, 14 HLA-B, seven HLA-C, seven HLA-DR and three HLA-DQ antigens was determined in 32 non-consanguineous white Brazilians suffering from chromoblastomycosis and 77 healthy controls, matched for ethnic background, sex and age and living in the same geographical area. A significant difference between the two groups was seen only in respect to one HLA-A antigen: A29 was present in 28% of patients as opposed to 4% of the controls (P corrected = 0.03). This finding indicates that susceptibility to chromoblastomycosis may be influenced by a gene located on chromosome 6, in the region of the major histocompatibility complex. The relative risk for an HLA-A29 carrier to develop chromoblastomycosis was estimated as 10.
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