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  • Title: Four new C10-polyacetylene glycosides from the rhizomes of Atractylodes lancea.
    Author: Xu K, Feng ZM, Yang YN, Jiang JS, Zhang PC.
    Journal: J Asian Nat Prod Res; 2017 Feb; 19(2):121-127. PubMed ID: 27790920.
    Abstract:
    An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C10-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds 2 and 3 showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM.
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