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  • Title: [Prostaglandins in Itsenko-Cushing syndrome].
    Author: Slavnov VN, Iakovlev AA, Komissarenko IV.
    Journal: Klin Med (Mosk); 1989 Jun; 67(6):94-8. PubMed ID: 2779163.
    Abstract:
    The results of the study of depressor (PGE+A) and pressor (PGF2 alpha) prostaglandins in the blood plasma and of PGE2 and PGF2 alpha excretion in the urine of 52 patients with an acute stage of Itsenko-Cushing disease are presented. It has been established that the different components of the PG system have dissimilar changes: the absence of differences in the content of depressor and significant increase in pressor PG, which may be the cause of hypertension in Itsenko-Cushing disease. Stress due to insulin hypoglycemia and furosemide load brought about disturbances in the reaction of the PG system, which were more pronounced in the system pressor component. Disturbances of the PG system which were more pronounced in the presence of stable hypertension were established in all patients.
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