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  • Title: Identification, localization, and role of fibronectin in cultured bovine endothelial cells.
    Author: Birdwell CR, Gospodarowicz D, Nicolson GL.
    Journal: Proc Natl Acad Sci U S A; 1978 Jul; 75(7):3273-7. PubMed ID: 277924.
    Abstract:
    We have examined bovine aortic endothelial cell cultures for the presence of fibronectin, a high molecular weight cell-surface glycoprotein. Sparse cultures contain fibronectin only on dorsal cell surfaces at regions of cell-cell contact, as detected by immunofluorescence. In contrast, when the endothelial cells reached confluence as a highly contact-inhibited monolayer, fibronectin was detected in an extracellular matrix underneath the cell monolayer but not on top of the monolayer. Sodium dodecyl sulfate/polyacrylamide gel electrophoresis of isolated extracellular matrix revealed that a predominant component of the matrix is a protein of approximately 2.3 X 10(5) molecular weight, which has been identified as fibronectin.
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