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  • Title: [Can naproxen impair menstruation?].
    Author: Meyboom RH, Bonsema K, Huisman-Klein Haneveld PM.
    Journal: Ned Tijdschr Geneeskd; 1989 Jul 01; 133(26):1326-7. PubMed ID: 2779679.
    Abstract:
    Two patients are described experiencing interruption of menstrual blood flow soon after taking a tablet of naproxen (250 or 275 mg). The patients were young women (19 and 34 years) with a diagnosis of primary dysmenorrhoea: menstruation had otherwise been regular and of normal duration. Normal menstruation is influenced by prostaglandins in a complex way. Non-steroidal anti-inflammatory drugs are known to reduce the amount of blood loss in menorrhagia. It is suggested that the effects of cyclo-oxygenase inhibitors on the metabolism of prostaglandins may occasionally interfere with the normal course of menstruation.
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