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  • Title: Medication Effects on EEG Biomarkers in Attention-Deficit/Hyperactivity Disorder.
    Author: Isiten HN, Cebi M, Sutcubasi Kaya B, Metin B, Tarhan N.
    Journal: Clin EEG Neurosci; 2017 Jul; 48(4):246-250. PubMed ID: 27798290.
    Abstract:
    EEG biomarkers have become increasingly used to aid in diagnosis of attention-deficit/hyperactivity disorder (ADHD). Despite several studies suggesting that EEG theta/beta ratio may help discriminating ADHD from other disorders, the effect of medications on theta/beta ratio is not known. Forty-three children with ADHD that were evaluated with quantitative EEG before and after methylphenidate were included in the study. Theta/beta ratio, theta and beta powers for whole brain, central, and frontal areas were calculated. Theta/beta power decreased significantly after treatment; however, this change was largely due to an increase in beta power, rather than a fall in theta power. The results suggest that beta power is sensitive to medication effects, while theta power remains as a trait biomarker unaffected by medication status. The value of EEG biomarkers for monitoring neuropsychological performance and clinical status should be explored by future studies.
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