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  • Title: Treatment of nonignorable missing data when modeling unobserved heterogeneity with finite mixture models.
    Author: Lehmann T, Schlattmann P.
    Journal: Biom J; 2017 Jan; 59(1):159-171. PubMed ID: 27804147.
    Abstract:
    Multiple imputation has become a widely accepted technique to deal with the problem of incomplete data. Typically, imputation of missing values and the statistical analysis are performed separately. Therefore, the imputation model has to be consistent with the analysis model. If the data are analyzed with a mixture model, the parameter estimates are usually obtained iteratively. Thus, if the data are missing not at random, parameter estimation and treatment of missingness should be combined. We solve both problems by simultaneously imputing values using the data augmentation method and estimating parameters using the EM algorithm. This iterative procedure ensures that the missing values are properly imputed given the current parameter estimates. Properties of the parameter estimates were investigated in a simulation study. The results are illustrated using data from the National Health and Nutrition Examination Survey.
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