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  • Title: Management of Sitagliptin and Metformin Combination Toxic Overdose.
    Author: Sehra S, Jaggi S, Sehra D, Aggarwal R, Saraswat V, Juneja D.
    Journal: J Assoc Physicians India; 2016 Nov; 64(11):80-81. PubMed ID: 27805342.
    Abstract:
    Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. Though toxicity is rare, but occurs more frequently in cases of intentional or unintentional overdose of these drugs. Here, we present a case of an intentional overdose of a metformin- sitagliptin combination (70g metformin and 3500mg sitagliptin) in a suicide attempt by a young non-diabetic female who presented with severe lactic acidosis and was successfully treated with prompt hemodialysis and bicarbonate therapy.
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