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  • Title: [Comparative studies of diatrizoate, ioxaglate and iohexol as angiocardiographic contrast media].
    Author: Esplugas E, Torrents A, Mauri J, Jara F.
    Journal: Rev Esp Cardiol; 1989 Mar; 42(3):173-6. PubMed ID: 2781110.
    Abstract:
    We did 2 consecutive randomized studies to compare the effects of diatrizoate, ioxaglate, and iohexol. Sixty patients were studied: 15 with diatrizoate (group I) versus 15 with ioxaglate (IIA), and 15 with ioxaglate (IIB) versus 15 with iohexol (III). Group I had hypotension and severe increase in end-diastolic pressure. Severe bradycardia was seen in 27% of the cases. Group IIA and IIB had identical changes, with a moderate increase in systolic and end-diastolic pressure. Group III only presented a mild increase in end-diastolic pressure. None of the low-osmolar contrast media produced severe bradycardia, but ioxaglate induced frequent (20%) nausea. Our results suggest the best contrast media for angiocardiography is, in decreasing order: iohexol, ioxaglate, and diatrizoate.
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