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  • Title: A new phenolic glycoside from Lindera nacusua.
    Author: Lei JP, Wei GQ, Yuan JJ, Tan KZ, Chen QY, Zhang T, Ma CY, Jiang HZ.
    Journal: Nat Prod Res; 2017 Apr; 31(8):896-901. PubMed ID: 27820967.
    Abstract:
    The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method. Compounds 9 and 10 showed moderate cytotoxicities with IC50 values ranging from 17.40 to 35.21 μM.
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