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  • Title: Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery.
    Author: Van Meirhaeghe J, Verdonk R, Verschraegen G, Myny P, Paeme G, Claessens H.
    Journal: Arch Orthop Trauma Surg; 1989; 108(5):308-13. PubMed ID: 2783023.
    Abstract:
    Two-hundred and fifty-two patients were included in a prospective, randomized, double-blind trial comparing the efficacy of flucloxacillin with that of cefazolin for clean orthopedic surgery. The preventive antibiotic regimen consisted of three 1-g injections perioperatively. There were 126 patients in each group, and the follow-up period was at least 6 months. Two deep (1.6%) and five superficial (4.0%) infections occurred in the flucloxacillin group. Three deep (2.4%) and five superficial (4.0%) infections developed in the cefazolin group.
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