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  • Title: Pharmacological manipulation of postoperative intestinal adhesions.
    Author: Sparnon AL, Spitz L.
    Journal: Aust N Z J Surg; 1989 Sep; 59(9):725-9. PubMed ID: 2783096.
    Abstract:
    Paralytic ileus and intestinal adhesions are common events following intra-abdominal surgery. The theoretical hypothesis 'that stimulation of the postoperative bowel will reduce intestinal adhesions' was studied in a rat model for intestinal adhesions in which postoperative bowel motility was pharmacologically manipulated. Immediate postoperative stimulation of gastrointestinal motility by the prokinetic agent, Cisapride, resulted in a significant reduction in both the number and extent of adhesions. Inhibition of postoperative intestinal motility with the anticholinergic agent, atropine, resulted in a greater number of more dense adhesions involving an increased length of bowel.
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