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  • Title: Transcriptome analysis of follicles reveals the importance of autophagy and hormones in regulating broodiness of Zhedong white goose.
    Author: Yu J, Lou Y, Zhao A.
    Journal: Sci Rep; 2016 Nov 11; 6():36877. PubMed ID: 27833138.
    Abstract:
    Broodiness, a maternal behavior and instinct for natural breeding in poultry, inhibits egg production and affects the poultry industry. Phenotypic and physiological factors influencing broodiness in poultry have been extensively studied, but the molecular regulation mechanism of broodiness remains unclear. Effective research strategies focusing on broodiness are hindered by limited understanding of goose developmental biology. Here we established the transcriptomes of goose follicles at egg-laying and broody stages by Illumina HiSeq platform and compared the sequenced transcriptomes of three types of follicles (small white, large white and small yellow). It was found that there were 92 up-regulated and 84 down-regulated transcription factors and 101 up-regulated and 51 down-regulated hormone-related genes. Many of these genes code for proteins involved in hormone response, follicular development, autophagy, and oxidation. Moreover, the contents of progesterone and estradiol in follicles were altered, and the autophagy levels of follicles were enhanced during the broody stage. These results suggest that hormone- and autophagy-signaling pathways are critical for controlling broodiness in the goose. We demonstrated that transcriptome analysis of egg-laying and broody Zhedong white goose follicles provided novel insights into broodiness in birds.
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