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  • Title: Efficacy and tolerability of fluoxetine in the elderly: a double-blind study versus amitryptiline.
    Author: Altamura AC, Percudani M, Guercetti G, Invernizzi G.
    Journal: Int Clin Psychopharmacol; 1989 Jan; 4 Suppl 1():103-6. PubMed ID: 2783697.
    Abstract:
    Twenty-eight elderly in-patients suffering from major depressive episodes received randomly, on a double-blind basis, amitryptiline or fluoxetine for 5 weeks. There were 4 drop-outs in the amitryptiline group and 2 drop-outs in the fluoxetine group. Both groups showed a significant amelioration at the end point for HRS-D scores compared to the baseline value. Anticholinergic side-effects were significantly more severe in the amitryptiline group. Weight gain was detected only in patients receiving amitryptiline.
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