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  • Title: Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.
    Author: Maruyama K, Tomizawa S, Shimabukuro N, Fukuda T, Johshita T, Kuroume T.
    Journal: Nephron; 1989; 51(1):73-6. PubMed ID: 2783765.
    Abstract:
    The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.
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