These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
    Author: Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC.
    Journal: Proc Natl Acad Sci U S A; 1989 Feb; 86(4):1168-72. PubMed ID: 2784003.
    Abstract:
    Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.
    [Abstract] [Full Text] [Related] [New Search]