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  • Title: Inhibition of acute anaphylaxis in the chicken by anti-allergic drugs.
    Author: Chand N, Eyre P.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Jun; 20(3):435-48. PubMed ID: 27847.
    Abstract:
    The anti-anaphylactic effects of four potential anti-allergic agents (DSCG: disodium cromoglycate, PRD-92-EA, M&B 22,948 and DECC: diethylcarbamazine citrate) were studied on cardiovascular responses of acute systemic anaphylaxis and chemical mediators of immediate hypersensitivity in chickens. Compounds M&B 22,948, PRD-92-EA, DSCG and DECC all inhibited cardiovascular manifestations of systemic anaphylaxis in domestic fowl. High doses of Compounds PRD-92 EA, M&B 22,948 and DECC also exhibited a nonspecific receptor blocking activity towards exogenously administered chemical mediators of anaphylaxis.
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