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  • Title: Proliferation of interleukin 2 dependent cytotoxic T cell line cells. Different protein kinase C activators achieve the same maximal promotion, but with distinct dose-response profiles.
    Author: Gavériaux C, Loor F.
    Journal: Int Arch Allergy Appl Immunol; 1989; 88(3):294-6. PubMed ID: 2785967.
    Abstract:
    Protein kinase C activators of the teleocidin family are claimed to be able to replace interleukin 2 for inducing short-term proliferation of the interleukin 2 dependent murine cytotoxic T cell line. While teleocidin B4 was found to be much more active than 12-O-tetradecanoyl-phorbol-13-acetate, a related molecule showing a substitution of a single OH by OCH3, olivoretin A, lacked detectable activity in this assay. However, the maximal proliferation achievable by protein kinase C activators did not exceed one third of the one given by recombinant interleukin 2.
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