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  • Title: Functional affinity of antibody to the Haemophilus influenzae type b polysaccharide.
    Author: Griswold WR, Lucas AH, Bastian JF, Garcia G.
    Journal: J Infect Dis; 1989 Jun; 159(6):1083-7. PubMed ID: 2786040.
    Abstract:
    The functional affinity, or avidity, of antibody to the capsular polysaccharide of Haemophilus influenzae (Hib-PS) was measured in serum samples from 12 adult male subjects before and after immunization with Hib-PS vaccine. Mean avidity increased from 0.74 nM-1 to 1.5 nM-1 after immunization (P less than .05, paired Student's t test). The Bureau of Biologics reference antiserum had an avidity constant of 12 nM-1, which was the highest of all 25 serum samples studied.
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